Now that I am on my mobile I can see the video. Bulb recorded all that with a Pod on the "treadplate" and/or "bigbottom" setting, a screamer w/ gain min vol maxed, 412 v30 sim, and lots of compression EQ and gating with the gain actually relatively low. However, when I played his Pod settings I never sounded like that. Watch the Premier Guitar Monsters of High Gain Shootout. Bulb sounds pretty much the same on every amp he plays with very little flavor differences.
As for what might get you closer to that with out the technique issue: boost with an overdrive. Turn the gain way down (like 9-10 oclock) add a compressor up front if you can. Really hit your strings hard. You need a thick pick for this type of sound. V30s would help. For a guitar, something 25.5" scale, mahogany body, and bright attacky pickups like BKP Painkillers, Evo, Lundgren or an EMG 81 would help out a lot also. I still say start with the Treadplate module, and go from there.
Keep in mind Bulb has what I like to call a "producer's ear" and because of this his tone sounds like absolute crap solo, but you throw it into a mix and it just fits perfectly.