I used to play EMGs back in the late 80's. Back then I was only playing metal and I wanted all of my guitars to sound the same.
In the early 90's I bought my first Tom Anderson guitar and I started experimenting with all of their pickups in my other guitars. I REALLY bonded with them.
DiMarzio's were very popular at the time and so I tried many of those and pretty much HATED every one of them. I couldn't tell you why. They all just had a character that didn't work for me.
I tried a few Duncans as well, but felt that the Anderson pickups worked best for me. I pretty much stuck with them until 2007. Then I went through almost EVERY Duncan humbucker and many Suhr models. I really HATED the Doug Aldrich pickup! Which was odd, because I really LOVE Doug Aldrich! I tried the new EVH fender pickups too. During all of this what I discovered was that lower output pickups gave me better tone, more dynamics and better sustain. The sound of my fingers was finally coming through!
The next pickups I bonded with were the Gibson Burst Bucker Pros! I tried a bunch of different Gibson pickups, but none of the others did it for me.
Next came Jason Lollar Imperials! AMAZING!!!! So harmonically rich and touch sensitive I couldn't believe it.
Everyone had been going on and on about Bare Knuckle pickups, so I tried a Riff Raff bridge pickup. It was good, but not great.
Then came the Railhammers!! The Hyper Vintage set is just WONDERFUL!!
Just today I received my Motor City Black Belt set!
I can't wait to try them!
On the other side of the pickup world I have a set of Rio Grande pickups in my Tele. Very twangy and vintage sounding and I couldn't be happier with them.
So in the end, I get my gain from my amp and not my pickups.
For an OD boost I have a Keeley modified Boss SD-1.
I keep the gain set very low and pretty much only use it for solos.
*For the record, all of my humbucker guitars use Basswood bodies and maple necks.