yes there is a difference but it is very subtle just a touch smoother
Really I think a lot depends on the preamp tubes you are using
if you are into modern preamp tubes the tung sol is a great option if you like bright and the reissue mullards and jj's are good for darker/smoother stuff (the jj ec803 has a little more mids and highs than the ec83s)
I have never really been a fan of the EHX tubes or really the Tung Sols for that matter the reissue Mullards are what I like for preamp tubes and JJ seems to be my choice for power tubes (at least for KT77, 6CA7, EL84, and 6V6)
then you can get into NOS tubes, JAN tubes, Genalex Gold Lions, etc and open a whole other can of worms.
Basically I think the most important thing is to just have low noise, low microphonic, functioning tubes they really don't play a big role in your tone despite popular belief or shall I say misconception
TONE is in the fingers the rest of the signal chain is really just that subtle tonal change.
I think the biggest difference makers you can do to an amp (aside from picking different amps/modules) are probably the speaker and in some instances transformers (upgrading to like a Mercury Magnetics can make a night and day difference). But that's just my opinion and as always YMMV.
But to my ear most current production tubes are just nothing special to write home about.