It is very nice to see the amount of useful replies on this topic. Apparently, the Plexi sound intrigues many guitar players including myself ;-)
However, it remains difficult to judge the nuances in sounds and feel of a preamp without trying it yourself. As far as i understood the comments, most of the Synergy modules are voiced in such a way that they also contain the modded, more high-gain variants of a vintage Marshall Super Lead amp.
In my own biased opinion, Plexi modules need to reproduce two main types of sounds which is the JimI Hendrix style bluesy sound (using volume control and neck element) and the typical AC/DC style sound (using the bridge pickup). My primary concern in selecting a module is that it will not sound too shrill or harsh...
But the Sound on Sound magazine also provide information on this typical Marshall Super Lead amp: "The Super Lead is a very bright-sounding amplifier: no modern design comes anywhere near to it for crunchy upper mid-range. There are other circuit factors involved as well, but a lot of the Super Lead's extreme treble comes from the use of a particularly large value 'bright cap' (capacitor) strapped across the lead channel's volume control (channels are actually just labelled I and II). At 5000pF it is more than 10 times the value commonly used in other amps, and it has a profound effect on the way the amp works. Bright caps allow high frequencies to bypass the volume pot, with their effect being greatest at low settings and diminishing eventually to nothing if the pot is turned all the way up. A 5000pF bright cap is passing not just high treble but a lot of mid-range too, so much so that it significantly skews the taper of the volume pot. At 3 on the dial a Super Lead is already rather loud, albeit uncomfortably thin and biting, but the bright cap begins to have less effect as you turn up further, until you reach an absolute 'sweet spot' at about 6. Latterly, there seems to have been a bit of forum mania for snipping the bright caps out of Super Leads, or at least just subbing them for a more conventional value. Admittedly, you probably end up with a more usable amplifier for today's requirements and volume restrictions, but it will no longer be a Super Lead, with its very particular brand of magic."
After reading this comment, i think that i prefer the Metro-Plex since the designer has probably gone more into detail on replicating this behavior in the circuitry?